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MC21 Project: accelerating innovation in oncology

Making every effort to cure even more patients: this is the goal of the MC21 project, for Marie Curie 21st century. This project, which will guide Institut Curie until 2021, is directly inspired by the model invented by Marie Curie in 1909, aimed at bringing researchers and physicians together to find new treatments for cancer patients without delay. Learn about the leading projects of this ambitious program.

The way of putting together the centromere

Cell separates correctly during cell division and gives rise to two daughter cells with identical genetic material. A complex mechanism largely leads by a small region of the chromosome: the centromere, frequently described as the heart of the chromosome, and also at the heart of the research of Daniele Fachinetti and his team.  

A new classification of cancers gives rise to a new avenue of treatment!

Thanks to Cytidine Deaminase, Mounira Amor-Guéret and her team are “classifying” cancers into two main sub-groups, independently of their tissue origin and of other currently used biomarkers, with a new avenue of treatment for the largest sub-group.

Déborah Bourc’his: the art of methylation

DNA methylation dictates the way in which the genome is expressed in the cells, and defines the specificities of each cell. From its introduction into the reproductive cells and the embryo to its disruption in tumorous cells, this phenomenon is gradually being revealed. We talk to Déborah Bourc’his, who has just made two important discoveries about its role in reproduction.

Sarcoma: nanoparticles to optimise treatment

The surgeon Sylvie Bonvalot, a specialist in soft tissue sarcomas, reveals the results of a clinical trial that used hafnium nanoparticles activated by radiotherapy before surgery for the first time. The results have just been published in Clinical Cancer Research.

Mechanics working in the cellular world

They present varying levels of hardness... Who? Cells! And beyond technological performance to determine their rigidity, it is also an indicator of their tumorous status.

November 9th: Join the #WomenInScience TweetChat with Geneviève Almouzni

November 9, 13.00 – 14.00. All are welcome to a Twitter chat/tweetchat organized by Novartis. The chat will feature thought leaders interested in advancing the careers of female scientists, using the hashtag #WomenInScience.

What do sarcoma cells and liquid crystals have in common?

The answer is their organisation in space. The elongated cells of the sarcoma run parallel to one another, like the molecules of a liquid crystal. Surprisingly, the physicists in Pascal Silberzan’s team showed that despite the motility of cells, and unlike other active systems, these cell populations avoid chaotic movements.

FACT, quality control of the heart of chromosomes

The DNA “pellet” in the core of our cells is constantly forming and unforming. Knowing how DNA is structured and potentially inherited during cell divisions is a major challenge in biology.

Triple negative breast cancer: combining radiotherapy with PARP inhibitors

This autumn at Institut Curie, a first patient suffering from a very aggressive form of breast cancer - triple negative breast cancer - will be offered a new therapeutic strategy. It involves increasing the effectiveness of radiotherapy and PARP inhibitors by combining them.

Leukaemia: discovery of an interrupter that causes the death of tumorous cells

Chemotherapy resistance and relapses are unfortunately still frequent in patients suffering from acute lymphoblastic T-cell leukaemia. The urgent issue for this rare blood cancer is to find new therapies, based on totally innovative approaches.

Childhood genetic disease: one sugar too many...

With its receptor “tied” in the wrong part of the cell membrane, the interferon ɤ is no longer able to perform its natural protective cytokine role. This results in a syndrome where severe and often fatal infections occur in young children. A mechanism being screened by Christophe Lamaze and his team, specialists in this key protein in immune defence. 

Fatima Mechta-Grigoriou: her battle against triple negative breast cancer

A breast cancer diagnosis can lead to a variety of outcomes. Although when detected early many breast cancers have relatively good outcomes, this is not the case for triple negative breast cancers, which too often leave physicians powerless.

For improved treatment of a rare tumour at the base of the skull, spinal column and sacrum

This clinical trial would never have taken place anywhere but at Institut Curie because it uses two cutting-edge technologies available to the Institut: proton therapy, thanks to the Cyclotron at Orsay and production of tagging agents able to reveal the target cells to be radiated thanks to AAA’s cyclotron (Advanced Accelerator Aplications) installed at the Saint-Cloud site. 

Samar Alsafadi : the eyes in uveal melanoma

At the end of May, Samar Alsafadi took over the Uveal Melanoma translational research group, an emerging team supported by SiRIC. The job is a perfect fit for this researcher, who prioritises interdisciplinary collaboration.

Toward immunotherapies tailored to each patient

Immunotherapy, already a highly promising solution, still has much more to offer, and its future is being developed today, in part by a new trial launched by Institut Curie. Its goal is to identify neoepitopes, phase one in offering customised immunotherapies.

Breast cancer: an alternative to neoadjuvant chemotherapy for post-menopausal women

Limiting the use of chemotherapy while still providing optimal care is certainly a desirable goal. To this end, Institute specialists have just proven the efficacy of a treatment based solely on hormone therapy.

Breast cancers: similarities between sub-families

There are multiple types of breast cancer, each type presenting different biological characteristics. The way each responds to treatments is different as well. Mapping the types of breast cancer is therefore essential.

The metronome of the embryo

Like waves in the ocean, rhythmic contractions propagate along the surface of mammalian embryos. Why and for which purpose? Jean-Léon Maître, a new researcher at Institut Curie who recently discovered this tempo, aims to uncover its secrets

Immunotherapy: specialists from Institut Curie present their results at ASCO 2016

This year once again, ASCO (American Society of Clinical Oncology), the world’s largest meeting on cancerology held June 3 to 7 in Chicago, focused on immunotherapy and precision medicine. In November Institut Curie will open the doors of its Centre for immunotherapy against cancer, and physician-researchers presented their latest findings in this field.