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Chemical library platform

The Institut Curie-CNRS bank of chemical compounds is the result of a 60-year effort to synthesize compounds for medicinal use. These substances are a variety of intermediate and end products obtained during optimization programs for various therapeutic targets.

Chemical library platform
Chimiothèque

Leaders

Claire Beauvineau
Florence Mahuteau-Betzer
Frédéric Schmidt

Activity

The Institute Curie/CNRS Chemical Library was created from the chemical molecules synthesized by the chemists of the Institute Curie of Paris (UMR3666 / U1143) and Orsay (UMR9187 / U1196). This academic chemical library, one of the most important of France, contains almost 10000 substances. Such a set of chemicals is constituted not only of the final products, but also of synthetic intermediates obtained during the programs of optimization against various therapeutic targets.

Since its creation, 65 years ago, the main motivation of the chemistry laboratory of the Institute Curie has been the discovery of molecules for cancer treatment. A direct consequence of this activity is the existence (often in significant quantities) of samples of several thousands of synthesized compounds. Moreover, advances in proteomics and genomics have led to the discovery of an increasing number of new protein targets with therapeutic potential.

By screening small molecules, either individually or, preferably, as collections called libraries of small molecules (chemical libraries), many opportunities are offered to discover or identify biologically active molecules, which are tools in "Chemical Biology" or “drugs of tomorrow”. In parallel the approach of rational conception, the serendipity is at the origin of the identification of many active ingredients. So, in coupling chemical libraries and platforms of screening, it is possible "to accelerate the fate". In this context, the chemical libraries of diverse institutes and French universities federated to form the National Chemical library (CN), this federation is supported by the CNRS (GIS-Chimiothèque nationale). This movement begun in 2001 was at the origin of the creation of the Chemical library of the institute Curie.

The compounds of the chemical library are available on 96 or 384 wells microplates directly usable for diverse tests. The Chemical library continues to grow by addition of the new molecules synthesized by the chemists.

Aims

As platform, the biologists in particular those of the Institute Curie and the customers of the National Chemical library can access to these molecules for selected assays by contract as part of a discovery partnership. The miniaturization and the automation of the biological tests allow screening the set or the part of the Chemical library to discover "Hits". The screenings can serve to select compounds which can interfere with biological phenomena. The results of these tests then give rise to scientific productions (publication and\or patent).

An expertise in chemical optimization of "Hit" (synthesis of structural analogues to establish for example a relation Structure / activity) is also proposed to the partner biologists by the platform Chemical library to understand better the involved biological phenomena or to improve the activity in a therapeutic purpose. The development of molecular tools to identify the biological targets of “hit” can be also envisaged at the end of the assays of chemical optimization. The screening of the chemical library thus leads to scientific collaborations between biologists and chemists.

Network

Chimiothèque Nationale CN "French Chemical Library" 

GDR ChemBioScreen 

GDR Chemoinformatique 

Contact

Claire Beauvineau (Chemistry, Modelling and Imaging for Biology, UMR9187/U1196) claire.beauvineau@curie.fr 

Tél. 01 69 86 71 59

Institut Curie
14/11/2013